(4-Methylamino-pyrrolidin-2-yl)-methanol → 5-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(5-hydroxymethyl-pyrrolidin-3-yl)-methyl-amino]-thiazol-4-one

HRID 955078Notes

Reaction equation

HRID 955078 reaction equation
[CH3:32][NH:33][CH:34]1[CH2:35][CH:36]([CH2:39][OH:40])[NH:37][CH2:38]1.[Cl:1][c:2]1[cH:3][c:4]([C:28]([F:29])([F:30])[F:31])[c:5]([CH2:6][n:7]2[n:8][cH:9][c:10]3[cH:11][c:12]([CH:16]=[C:17]4[C:18](=[O:25])[NH:19][CH:20]([S:22][CH2:23][CH3:24])[S:21]4)[cH:13][cH:14][c:15]23)[cH:26][cH:27]1>>[Cl:1][c:2]1[cH:3][c:4]([C:28]([F:29])([F:30])[F:31])[c:5]([CH2:6][n:7]2[n:8][cH:9][c:10]3[cH:11][c:12]([CH:16]=[C:17]4[C:18](=[O:25])[N:19]=[C:20]([N:33]([CH3:32])[CH:34]5[CH2:35][CH:36]([CH2:39][OH:40])[NH:37][CH2:38]5)[S:21]4)[cH:13][cH:14][c:15]23)[cH:26][cH:27]1

Participants

3

Reactant 2

HCID 57560783(4-Methylamino-pyrrolidin-2-yl)-methanolHCID 866565235-[1-(4-chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-ethylsulfanyl-thiazolidin-4-one

Product 1

HCID 673458775-[1-(4-Chloro-2-trifluoromethyl-benzyl)-1H-indazol-5-ylmethylene]-2-[(5-hydroxymethyl-pyrrolidin-3-yl)-methyl-amino]-thiazol-4-one

Sources & evidence

ORD record
ord-4297c5d2866e41aa8b5ae7ca402745da
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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