Dichloromethane → N-[2-(3,4-dichlorophenyl)-4-[4-(2-oxopiperidin-1-yl)piperidin-1-yl]butyl]-4-fluoro-N-methylbenzamide
Reaction equation
[Cl:11][c:12]1[cH:13][c:14]([CH:19]([CH2:20][CH2:21][N:22]2[CH2:23][CH2:24][CH:25]([N:28]3[C:29](=[O:34])[CH2:30][CH2:31][CH2:32][CH2:33]3)[CH2:26][CH2:27]2)[CH2:35][NH:36][CH3:37])[cH:15][cH:16][c:17]1[Cl:18].[Cl:38][CH2:39][Cl:40].[F:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[Cl:8])[cH:9][cH:10]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[N:36]([CH2:35][CH:19]([c:14]2[cH:13][c:12]([Cl:11])[c:17]([Cl:18])[cH:16][cH:15]2)[CH2:20][CH2:21][N:22]2[CH2:23][CH2:24][CH:25]([N:28]3[C:29](=[O:34])[CH2:30][CH2:31][CH2:32][CH2:33]3)[CH2:26][CH2:27]2)[CH3:37])[cH:9][cH:10]1Participants
4
Sources & evidence
- ORD record
- ord-21fbdbf3c7b34d6480d493a638fedc36
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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