2-Piperidin-2-ylethanol → 4-[7-(2-Piperidin-2-yl-ethoxy)-quinazolin-4-yl]-piperidine-1-carboxylic acid (4-morpholin-4-yl-phenyl)-amide

HRID 955144Notes

Reaction equation

HRID 955144 reaction equation
[NH:33]1[CH:34]([CH2:39][CH2:40][OH:41])[CH2:35][CH2:36][CH2:37][CH2:38]1.[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[cH:8][cH:9][c:10]([NH:13][C:14](=[O:15])[N:16]3[CH2:17][CH2:18][CH:19]([c:22]4[n:23][cH:24][n:25][c:26]5[cH:27][c:28]([F:32])[cH:29][cH:30][c:31]45)[CH2:20][CH2:21]3)[cH:11][cH:12]2)[CH2:5][CH2:6]1>>[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[cH:8][cH:9][c:10]([NH:13][C:14](=[O:15])[N:16]3[CH2:17][CH2:18][CH:19]([c:22]4[n:23][cH:24][n:25][c:26]5[cH:27][c:28]([O:41][CH2:40][CH2:39][CH:34]6[NH:33][CH2:38][CH2:37][CH2:36][CH2:35]6)[cH:29][cH:30][c:31]45)[CH2:20][CH2:21]3)[cH:11][cH:12]2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 151442-Piperidin-2-ylethanolHCID 587707764-(7-Fluoro-quinazolin-4-yl)-piperidine-1-carboxylic acid (4-morpholin-4-yl-phenyl)-amide

Product 1

HCID 587706334-[7-(2-Piperidin-2-yl-ethoxy)-quinazolin-4-yl]-piperidine-1-carboxylic acid (4-morpholin-4-yl-phenyl)-amide

Sources & evidence

ORD record
ord-5f15f02058a14146ad6935beac669d9a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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