Potassium Cation → 4-[1-(3-Hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one

HRID 955200Notes

Reaction equation

HRID 955200 reaction equation
[Br:24][c:25]1[cH:26][n:27][n:28]([CH2:30][CH2:31][CH2:32][OH:33])[cH:29]1.[C:37](=[O:38])([O-:39])[O-:40].[CH3:1][N:2]1[C:3](=[O:23])[c:4]2[c:5]([N+:20](=[O:21])[O-:22])[cH:6][cH:7][c:8]([B:11]3[O:12][C:13]([CH3:14])([CH3:15])[C:16]([CH3:17])([CH3:18])[O:19]3)[c:9]2[CH2:10]1.[Cl:34][CH2:35][Cl:36].[K+:41].[K+:42].[O:44]1[CH2:45][CH2:46][O:47][CH2:48][CH2:49]1.[OH2:43]>>[CH3:1][N:2]1[C:3](=[O:23])[c:4]2[c:5]([N+:20](=[O:21])[O-:22])[cH:6][cH:7][c:8](-[c:25]3[cH:26][n:27][n:28]([CH2:30][CH2:31][CH2:32][OH:33])[cH:29]3)[c:9]2[CH2:10]1

Participants

8

Reactant 7

HCID 813Potassium Cation2×HCID 962WaterHCID 6344DichloromethaneHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 166406443-(4-bromo-1H-pyrazol-1-yl)propan-1-olHCID 672539682-Methyl-7-nitro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-isoindol-1-one

Product 1

HCID 672550944-[1-(3-Hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-7-nitro-2,3-dihydro-1H-isoindol-1-one

Sources & evidence

ORD record
ord-b8f45242e2b947318aa79325da04d085
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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