Methanol → tert-Butyl 4-amino-3-methylpiperidine-1-carboxylate

HRID 955202Notes

Reaction equation

HRID 955202 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH3:23])[CH:11]([NH:14][CH:15]([c:16]2[cH:17][cH:18][cH:19][cH:20][cH:21]2)[CH3:22])[CH2:12][CH2:13]1.[CH3:24][OH:25].[OH-:26].[OH-:28].[Pd+2:27]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([CH3:23])[CH:11]([NH2:14])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 20871947tert-Butyl 3-methyl-4-((1-phenylethyl)amino)piperidine-1-carboxylate

Product 1

HCID 51358548tert-Butyl 4-amino-3-methylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-adedd6e70dd94467b89e0e1bd890a4a5
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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