Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylate → Ethyl 2-[4-(6-chloro-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylate

HRID 955378Notes

Reaction equation

HRID 955378 reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7]([C:13]([F:14])([F:15])[F:16])[n:8][c:9]([Cl:12])[n:10][cH:11]1.[Cl:17][c:18]1[n:19][n:20][c:21]([N:26]2[CH2:27][CH:28]([CH3:32])[NH:29][CH2:30][CH2:31]2)[c:22]([CH3:25])[c:23]1[CH3:24]>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7]([C:13]([F:14])([F:15])[F:16])[n:8][c:9]([N:29]2[CH:28]([CH3:32])[CH2:27][N:26]([c:21]3[n:20][n:19][c:18]([Cl:17])[c:23]([CH3:24])[c:22]3[CH3:25])[CH2:31][CH2:30]2)[n:10][cH:11]1

Participants

3

Reactant 2

HCID 2780355Ethyl 2-chloro-4-(trifluoromethyl)pyrimidine-5-carboxylateHCID 725393803-Chloro-4,5-dimethyl-6-(3-methylpiperazin-1-yl)pyridazine

Product 1

HCID 72539345Ethyl 2-[4-(6-chloro-4,5-dimethylpyridazin-3-yl)-2-methylpiperazin-1-yl]-4-(trifluoromethyl)pyrimidine-5-carboxylate

Sources & evidence

ORD record
ord-4fb282d7797a474f9508841ce148e660
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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