Acetate → Ethyl 5-(3,3-dimethylpiperazin-1-yl)thiophene-2-carboxylate

HRID 955886Notes

Reaction equation

HRID 955886 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[s:6]1.[C:20](=[O:21])([O-:22])[O-:23].[CH3:12][C:13]1([CH3:19])[NH:14][CH2:15][CH2:16][NH:17][CH2:18]1.[CH3:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.[Cs+:24].[Cs+:25].[O-:34][C:35]([CH3:36])=[O:37].[O-:38][C:39]([CH3:40])=[O:41].[Pd+2:33]>>[c:2]1([N:17]2[CH2:16][CH2:15][NH:14][C:13]([CH3:12])([CH3:19])[CH2:18]2)[cH:3][cH:4][c:5]([C:7](=[O:8])[O:9][CH2:10][CH3:11])[s:6]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1140TolueneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 605723Ethyl 5-bromothiophene-2-carboxylateHCID 146641862,2-Dimethylpiperazine

Product 1

HCID 66589679Ethyl 5-(3,3-dimethylpiperazin-1-yl)thiophene-2-carboxylate

Sources & evidence

ORD record
ord-ec498043e60c4029a493bd8dc7162120
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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