4-[2-(Trifluoromethyl)phenyl]piperidine → (6-Chloro-1H-indol-3-yl)-[4-(2-trifluoromethyl-phenyl)-piperidin-1-yl]-methanone
Reaction equation
[Cl:17][c:18]1[cH:19][cH:20][c:21]2[c:22]([C:27](=[O:28])[OH:29])[cH:23][nH:24][c:25]2[cH:26]1.[F:1][C:2]([c:3]1[c:4]([CH:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)[cH:5][cH:6][cH:7][cH:8]1)([F:15])[F:16]>>[F:1][C:2]([c:3]1[c:4]([CH:9]2[CH2:10][CH2:11][N:12]([C:27]([c:22]3[c:21]4[cH:20][cH:19][c:18]([Cl:17])[cH:26][c:25]4[nH:24][cH:23]3)=[O:28])[CH2:13][CH2:14]2)[cH:5][cH:6][cH:7][cH:8]1)([F:15])[F:16]Participants
3
Sources & evidence
- ORD record
- ord-34952f5ca7b9432cb3749304fa43f035
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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