Dimethyl Sulfoxide → tert-Butyl ({4-[4-chloro-2-(2-formylpyridin-4-yl)phenoxy]-2,5-difluorophenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

HRID 956111Notes

Reaction equation

HRID 956111 reaction equation
[C:42](=[O:43])([O-:44])[O-:45].[CH3:49][S:50](=[O:51])[CH3:52].[Cl:1][c:2]1[cH:3][cH:4][c:5]([OH:16])[c:6](-[c:8]2[cH:9][c:10]([CH:14]=[O:15])[n:11][cH:12][cH:13]2)[cH:7]1.[K+:46].[K+:47].[OH2:48].[s:17]1[cH:18][n:19][c:20]([N:22]([C:23]([O:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:29])[S:30](=[O:31])(=[O:32])[c:33]2[c:34]([F:41])[cH:35][c:36]([F:40])[c:37]([F:39])[cH:38]2)[cH:21]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([O:16][c:36]2[cH:35][c:34]([F:41])[c:33]([S:30]([N:22]([c:20]3[n:19][cH:18][s:17][cH:21]3)[C:23]([O:24][C:25]([CH3:26])([CH3:27])[CH3:28])=[O:29])(=[O:31])=[O:32])[cH:38][c:37]2[F:39])[c:6](-[c:8]2[cH:9][c:10]([CH:14]=[O:15])[n:11][cH:12][cH:13]2)[cH:7]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 59436528tert-Butyl 1,3-thiazol-4-yl[(2,4,5-trifluorophenyl)sulfonyl]carbamateHCID 1360636234-(5-Chloro-2-hydroxyphenyl)pyridine-2-carbaldehyde

Product 1

HCID 59436611tert-Butyl ({4-[4-chloro-2-(2-formylpyridin-4-yl)phenoxy]-2,5-difluorophenyl}sulfonyl)1,3-thiazol-4-ylcarbamate

Sources & evidence

ORD record
ord-339cd395db40410885e8b62bd77ed100
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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