Dichloromethane → 5-Chloromethyl-4-cyclopropyl-6-methoxymethyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

HRID 956224Notes

Reaction equation

HRID 956224 reaction equation
[CH:1]1([c:4]2[n:5][c:6](-[c:15]3[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]3)[n:7][c:8]([CH2:12][O:13][CH3:14])[c:9]2[CH2:10][OH:11])[CH2:2][CH2:3]1.[Cl:29][CH2:30][Cl:31].[S:25]([Cl:26])([Cl:27])=[O:28]>>[CH:1]1([c:4]2[n:5][c:6](-[c:15]3[cH:16][cH:17][c:18]([C:21]([F:22])([F:23])[F:24])[cH:19][cH:20]3)[n:7][c:8]([CH2:12][O:13][CH3:14])[c:9]2[CH2:10][Cl:27])[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24386Thionyl ChlorideHCID 21935658HCID 21935658, compound

Product 1

HCID 219357905-Chloromethyl-4-cyclopropyl-6-methoxymethyl-2-(4-trifluoromethyl-phenyl)-pyrimidine

Sources & evidence

ORD record
ord-a6e10878d5e445cdae15374e39491a15
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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