Methanol → 3-Methoxymethyl-2,5-difluoro-4-(4-ethoxycarbonyl-1-piperazinyl)nitrobenzene

HRID 956575Notes

Reaction equation

HRID 956575 reaction equation
[CH3:31][OH:32].[F:1][c:2]1[c:3]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH2:18][CH2:19]2)[c:4]([CH2:5][OH:6])[c:7]([F:13])[c:8]([N+:10](=[O:11])[O-:12])[cH:9]1.[OH2:30].[S:25](=[O:26])(=[O:27])([OH:28])[OH:29]>>[F:1][c:2]1[c:3]([N:14]2[CH2:15][CH2:16][N:17]([C:20](=[O:21])[O:22][CH2:23][CH3:24])[CH2:18][CH2:19]2)[c:4]([CH2:5][O:6][CH3:31])[c:7]([F:13])[c:8]([N+:10](=[O:11])[O-:12])[cH:9]1

Participants

5

Reactant 4

HCID 887MethanolHCID 962WaterHCID 1118Sulfuric AcidHCID 156225283,6-Difluoro-2-(4-ethoxycarbonyl-1-piperazinyl)-5-nitrobenzyl alcohol

Product 1

HCID 198411483-Methoxymethyl-2,5-difluoro-4-(4-ethoxycarbonyl-1-piperazinyl)nitrobenzene

Sources & evidence

ORD record
ord-05705dd713074f71ada9006c317fc90a
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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