Chloroform → Ethyl 4-{2-[(3,5-bis-trifluoromethyl-benzyl)-(3-bromo-2-hydroxy-5-trifluoromethyl-benzyl)-amino]-pyrimidin-5-yloxy}-butyrate
Reaction equation
[Br:44][N:45]1[C:46](=[O:47])[CH2:48][CH2:49][C:50]1=[O:51].[CH:52]([Cl:53])([Cl:54])[Cl:55].[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]([c:8]2[n:9][cH:10][c:11]([O:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[O:20][CH2:21][CH3:22])[cH:12][n:13]2)[CH2:23][c:24]2[c:25]([OH:34])[cH:26][cH:27][c:28]([C:30]([F:31])([F:32])[F:33])[cH:29]2)[cH:35][c:36]([C:38]([F:39])([F:40])[F:41])[cH:37]1)([F:42])[F:43]>>[F:1][C:2]([c:3]1[cH:4][c:5]([CH2:6][N:7]([c:8]2[n:9][cH:10][c:11]([O:14][CH2:15][CH2:16][CH2:17][C:18](=[O:19])[O:20][CH2:21][CH3:22])[cH:12][n:13]2)[CH2:23][c:24]2[c:25]([OH:34])[c:26]([Br:44])[cH:27][c:28]([C:30]([F:31])([F:32])[F:33])[cH:29]2)[cH:35][c:36]([C:38]([F:39])([F:40])[F:41])[cH:37]1)([F:42])[F:43]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-a4a05cfe59f84a73b2a66f4af0203ca3
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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