2-chloro-6-(trifluoromethyl)-1H-benzimidazole → 2-[4-(8-Hydroxyquinolin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole
Reaction equation
[Cl:18][c:19]1[n:20][c:21]2[c:22]([nH:23]1)[cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]2.[OH:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][c:9]([N:12]3[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]3)[n:10][c:11]12>>[OH:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][c:9]([N:12]3[CH2:13][CH2:14][N:15]([c:19]4[n:20][c:21]5[c:22]([nH:23]4)[cH:24][c:25]([C:28]([F:29])([F:30])[F:31])[cH:26][cH:27]5)[CH2:16][CH2:17]3)[n:10][c:11]12Participants
3
Sources & evidence
- ORD record
- ord-06c7ef6271bb482980431470eabcc054
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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