Bis-(4-methoxybenzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine → 4-(2-aminopyrimidin-5-yl)-N-[5-(4-ethylpiperazin-1-yl)-2-methylphenyl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidine-7-carbothioamide
Reaction equation
[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][N:8]([CH2:9][c:10]2[cH:11][cH:12][c:13]([O:14][CH3:15])[cH:16][cH:17]2)[c:18]2[n:19][cH:20][c:21](-[c:22]3[c:23]4[c:27]([n:28][c:29]([N:30]5[CH2:31][CH2:32][O:33][CH2:34][CH2:35]5)[n:36]3)[NH:26][CH2:25][CH2:24]4)[cH:37][n:38]2)[cH:39][cH:40]1.[CH3:41][c:42]1[cH:43][cH:44][c:45]([N:46]2[CH2:47][CH2:48][N:49]([CH2:50][CH3:51])[CH2:52][CH2:53]2)[cH:54][c:55]1[NH2:56].[CH3:57][c:58]1[c:59]([NH:72][C:73](=[S:74])[N:75]2[CH2:76][CH2:77][c:78]3[c:79]2[n:80][c:81]([N:109]2[CH2:110][CH2:111][O:112][CH2:113][CH2:114]2)[n:82][c:83]3-[c:84]2[cH:85][n:86][c:87]([N:90]([CH2:91][c:92]3[cH:93][cH:94][c:95]([O:96][CH3:97])[cH:98][cH:99]3)[CH2:100][c:101]3[cH:102][cH:103][c:104]([O:105][CH3:106])[cH:107][cH:108]3)[n:88][cH:89]2)[cH:60][c:61]([N:64]2[CH2:65][CH2:66][N:67]([CH2:70][CH3:71])[CH2:68][CH2:69]2)[cH:62][cH:63]1>>[CH3:57][c:58]1[c:59]([NH:72][C:73](=[S:74])[N:75]2[CH2:76][CH2:77][c:78]3[c:79]2[n:80][c:81]([N:109]2[CH2:110][CH2:111][O:112][CH2:113][CH2:114]2)[n:82][c:83]3-[c:84]2[cH:85][n:86][c:87]([NH2:90])[n:88][cH:89]2)[cH:60][c:61]([N:64]2[CH2:65][CH2:66][N:67]([CH2:70][CH3:71])[CH2:68][CH2:69]2)[cH:62][cH:63]1Participants
4
Reactant 3
HCID 45258862Bis-(4-methoxybenzyl)-[5-(2-morpholin-4-yl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)-pyrimidin-2-yl]-amine
HCID 629105465-(4-Ethyl-1-piperazinyl)-2-methylbenzenamine
HCID 873803284-[2-[bis[(4-methoxyphenyl)methyl]amino]pyrimidin-5-yl]-N-[5-(4-ethylpiperazin-1-yl)-2-methylphenyl]-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidine-7-carbothioamideProduct 1
Sources & evidence
- ORD record
- ord-eddffccc6e0648268e635907615f2f62
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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