Ethyl 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate → 2-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid

HRID 956692Notes

Reaction equation

HRID 956692 reaction equation
[F:1][C:2]1([F:3])[CH2:4][CH:5]1[CH2:6][N:7]1[CH2:8][CH2:9][N:10]([c:11]2[s:12][c:13]([C:14]([O:15][CH2:16][CH3:17])=[O:18])[c:19]([CH3:20])[n:21]2)[C:22]1=[O:23].[F:24][c:25]1[cH:26][cH:27][c:28]([CH2:29][N:30]2[C:31](=[O:46])[N:32]([c:35]3[s:36][c:37]([C:41](=[O:42])[O:43][CH2:44][CH3:45])[c:38]([CH3:40])[n:39]3)[CH2:33][CH2:34]2)[cH:47][cH:48]1>>[F:24][c:25]1[cH:26][cH:27][c:28]([CH2:29][N:30]2[C:31](=[O:46])[N:32]([c:35]3[s:36][c:37]([C:41](=[O:42])[OH:43])[c:38]([CH3:40])[n:39]3)[CH2:33][CH2:34]2)[cH:47][cH:48]1

Participants

3

Reactant 2

HCID 57919911Ethyl 2-(3-(4-fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylateHCID 57919981Ethyl 2-(3-((2,2-difluorocyclopropyl)methyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate

Product 1

HCID 579197992-(3-(4-Fluorobenzyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acid

Sources & evidence

ORD record
ord-c0847b369c92471fa58b206548d152f7
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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