3-Pyridinemethanamine → N-[(3,4-difluorophenyl)methyl]-2-[3-[(4-fluorophenyl)methyl]-4-methyl-2-oxoimidazolidin-1-yl]-4-methyl-1,3-thiazole-5-carboxamide
Reaction equation
[F:19][c:20]1[cH:21][cH:22][c:23]([CH2:24][N:25]2[C:26](=[O:40])[N:27]([c:31]3[s:32][c:33]([C:37](=[O:38])[OH:39])[c:34]([CH3:36])[n:35]3)[CH2:28][CH:29]2[CH3:30])[cH:41][cH:42]1.[F:43][c:44]1[cH:45][cH:46][c:47]([CH2:48][N:49]2[CH:50]([CH3:51])[CH2:52][N:53]([c:54]3[s:55][c:56]([C:57]([OH:58])=[O:59])[c:60]([CH3:61])[n:62]3)[C:63]2=[O:64])[cH:65][cH:66]1.[F:9][c:10]1[cH:11][c:12]([CH2:13][NH2:14])[cH:15][cH:16][c:17]1[F:18].[n:1]1[cH:2][cH:3][cH:4][c:5]([CH2:6][NH2:7])[cH:8]1>>[F:9][c:10]1[cH:11][c:12]([CH2:13][NH:14][C:37]([c:33]2[s:32][c:31]([N:27]3[C:26](=[O:40])[N:25]([CH2:24][c:23]4[cH:22][cH:21][c:20]([F:19])[cH:42][cH:41]4)[CH:29]([CH3:30])[CH2:28]3)[n:35][c:34]2[CH3:36])=[O:38])[cH:15][cH:16][c:17]1[F:18]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-1067db29f44a453da5834206110fc474
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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