2-Chloro-5-nitropyridine → 6-[4-(2-Trifluoromethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylamine

HRID 957059Notes

Reaction equation

HRID 957059 reaction equation
[Cl:24][c:25]1[cH:26][cH:27][c:28]([N+:29]([O-:30])=[O:31])[cH:32][n:33]1.[F:1][C:2]([F:3])([F:4])[c:5]1[cH:6][c:7]([CH:8]2[CH2:10][CH2:11][N:12]([c:15]3[n:16][cH:17][c:18]([NH2:21])[cH:19][cH:20]3)[CH2:13][CH2:14]2)[cH:9][cH:22][cH:23]1.[F:34][C:35]([c:36]1[c:37]([N:42]2[CH2:43][CH2:44][NH:45][CH2:46][CH2:47]2)[cH:38][cH:39][cH:40][cH:41]1)([F:48])[F:49]>>[CH2:10]1[CH2:11][N:12]([c:15]2[n:16][cH:17][c:18]([NH2:21])[cH:19][cH:20]2)[CH2:13][CH2:14][N:42]1[c:37]1[c:36]([C:35]([F:34])([F:48])[F:49])[cH:41][cH:40][cH:39][cH:38]1

Participants

4

Reactant 3

HCID 783082-Chloro-5-nitropyridineHCID 27776701-[2-(Trifluoromethyl)phenyl]piperazineHCID 593712454-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-ylamine

Product 1

HCID 593712376-[4-(2-Trifluoromethyl-phenyl)-piperazin-1-yl]-pyridin-3-ylamine

Sources & evidence

ORD record
ord-426d905714a741c2b5072145828da52f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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