Dichloromethane → 5-Bromo-3-(5-(4-Ethylpiperazin-1-yl)pyridin-2-ylamino)-1-methylpyridin-2(1H)-one
Reaction equation
[Br:16][c:17]1[c:18](=[O:25])[n:19]([CH3:24])[cH:20][c:21]([Br:23])[cH:22]1.[C:26](=[O:27])([O-:28])[O-:29].[CH2:1]([CH3:2])[N:3]1[CH2:4][CH2:5][N:6]([c:9]2[cH:10][cH:11][c:12]([NH2:15])[n:13][cH:14]2)[CH2:7][CH2:8]1.[Cl:94][CH2:95][Cl:96].[Cs+:30].[Cs+:31].[O:32]1[CH2:33][CH2:34][O:35][CH2:36][CH2:37]1.[O:40]=[C:41]([CH:42]=[CH:43][c:44]1[cH:45][cH:46][cH:47][cH:48][cH:49]1)[CH:50]=[CH:51][c:52]1[cH:53][cH:54][cH:55][cH:56][cH:57]1.[O:58]=[C:59]([CH:60]=[CH:61][c:62]1[cH:63][cH:64][cH:65][cH:66][cH:67]1)[CH:68]=[CH:69][c:70]1[cH:71][cH:72][cH:73][cH:74][cH:75]1.[O:76]=[C:77]([CH:78]=[CH:79][c:80]1[cH:81][cH:82][cH:83][cH:84][cH:85]1)[CH:86]=[CH:87][c:88]1[cH:89][cH:90][cH:91][cH:92][cH:93]1.[Pd:38].[Pd:39]>>[CH2:1]([CH3:2])[N:3]1[CH2:4][CH2:5][N:6]([c:9]2[cH:10][cH:11][c:12]([NH:15][c:17]3[c:18](=[O:25])[n:19]([CH3:24])[cH:20][c:21]([Br:23])[cH:22]3)[n:13][cH:14]2)[CH2:7][CH2:8]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-cfeebd37c94d47f7895305ea2092406f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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