4-(3-Amino-2-hydroxypropoxy)-1,3-dihydrobenzimidazol-2-one → 5-[[4-[4-[[2-Hydroxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]propyl]amino]piperidin-1-yl]phenyl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one

HRID 957150Notes

Reaction equation

HRID 957150 reaction equation
[O:1]1[CH2:2][CH2:3][N:4]([C:7]2=[N:11][C:10](=[O:12])[C:9](=[CH:13][c:14]3[cH:15][cH:16][c:17]([N:20]4[CH2:21][CH2:22][C:23](=[O:26])[CH2:24][CH2:25]4)[cH:18][cH:19]3)[S:8]2)[CH2:5][CH2:6]1.[OH:27][CH:28]([CH2:29][O:30][c:31]1[cH:32][cH:33][cH:34][c:35]2[nH:36][c:37](=[O:40])[nH:38][c:39]12)[CH2:41][NH2:42]>>[O:1]1[CH2:2][CH2:3][N:4]([C:7]2=[N:11][C:10](=[O:12])[C:9](=[CH:13][c:14]3[cH:15][cH:16][c:17]([N:20]4[CH2:21][CH2:22][CH:23]([NH:42][CH2:41][CH:28]([OH:27])[CH2:29][O:30][c:31]5[cH:32][cH:33][cH:34][c:35]6[nH:36][c:37](=[O:40])[nH:38][c:39]56)[CH2:24][CH2:25]4)[cH:18][cH:19]3)[S:8]2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 158962374-(3-Amino-2-hydroxypropoxy)-1,3-dihydrobenzimidazol-2-oneHCID 699211351-[4-(2-morpholin-4-yl-4-oxo-4H-thiazol-5-ylidenemethyl)-phenyl]-piperidin-4-one

Product 1

HCID 700235635-[[4-[4-[[2-Hydroxy-3-[(2-oxo-1,3-dihydrobenzimidazol-4-yl)oxy]propyl]amino]piperidin-1-yl]phenyl]methylidene]-2-morpholin-4-yl-1,3-thiazol-4-one

Sources & evidence

ORD record
ord-6cbd8ec155054cffb40f71d92d059b65
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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