4-Ethoxycarbonylphenylboronic acid → 4-[1-(2-Chloro-3,6-difluorobenzyl)-2-oxo-1,2,3,4-tetrahydropyrido[2,3-b]pyrazin-7-yl]benzoic acid ethyl ester
Reaction equation
[CH2:23]([CH3:24])[O:25][C:26](=[O:27])[c:28]1[cH:29][cH:30][c:31]([B:34]([OH:35])[OH:36])[cH:32][cH:33]1.[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:12][cH:13][c:14]([I:16])[cH:15]3)[NH:8][CH2:9][C:10]2=[O:11])[c:17]([F:22])[cH:18][cH:19][c:20]1[F:21]>>[Cl:1][c:2]1[c:3]([CH2:4][N:5]2[c:6]3[c:7]([n:12][cH:13][c:14](-[c:31]4[cH:30][cH:29][c:28]([C:26]([O:25][CH2:23][CH3:24])=[O:27])[cH:33][cH:32]4)[cH:15]3)[NH:8][CH2:9][C:10]2=[O:11])[c:17]([F:22])[cH:18][cH:19][c:20]1[F:21]Participants
3
Sources & evidence
- ORD record
- ord-12403ee0a4604960b700cfec9cf4920e
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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