反应详情

Sulfuryl chloride (50 μL, 0.65 mmol) was added neat to 5-fluoro-1,3-benzothiazole-2-thiol (100 mg, 0.54 mmol). The mixture was stirred at ambient temperature for 1 h, then heated at 60° C. for 30 minutes. The resulting solution was cooled to rt, and poured onto ice. The title compound was collected by filtration, washed with water, and dried under vacuum. The solid obtained was used without further purification; LC-MS m/z 188.1 (MH+), ret. time 3.27 min.

1. temperatureheated at 60° C. for 30 minutes
2. temperatureThe resulting solution was cooled to rt
3. additionpoured onto ice
4. filtrationThe title compound was collected by filtration
5. washwashed with water
6. customdried under vacuum
7. customThe solid obtained
8. customwas used without further purification