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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 957476Generated: October 25, 2026

Acetate → 2-(trans-4-Hydroxycyclohexyl)-7-[4-(trifluoromethyl)phenyl]-2,7-diazaspiro[4.5]decan-1-one

https://huagongshe.com/reaction/957476

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetateHCID 175—
ReactantHydrochloric AcidHCID 313—
ReactantSodium ionHCID 923—
Reactant1,4-DioxaneHCID 31275—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReactantAllyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 105144—
Reactant2-(Di-tert-butylphosphino)biphenylHCID 2734215—
Reactant2-Methylpropan-2-olateHCID 4574913—
Reactant2-(4-Hydroxycyclohexyl)-2,9-diazaspiro[4.5]decan-1-oneHCID 57970939—
Product2-(trans-4-Hydroxycyclohexyl)-7-[4-(trifluoromethyl)phenyl]-2,7-diazaspiro[4.5]decan-1-oneHCID 11574792—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-b4b6fafd4b6e43ba9535fbf660aa6bf2
Source noteValidation data from https://doi.org/10.1039/C8SC04228D