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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 957523Generated: October 30, 2026

Dimethylformamide → 2-Amino-1-ethyl-7-(3-methyl-3-trimethylsilanyloxybut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide

https://huagongshe.com/reaction/957523

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethylformamideHCID 6228—
ReactantTriethylamineHCID 8471—
ReactantTriphenylphosphineHCID 11776—
ReactantPalladium ChlorideHCID 24290—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
Reactant((1,1-Dimethyl-2-propynyl)oxy)trimethylsilaneHCID 87344—
Reactant2-Amino-7-chloro-1-ethyl-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamideHCID 86642336—
Product2-Amino-1-ethyl-7-(3-methyl-3-trimethylsilanyloxybut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamideHCID 67081455—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-396ae731a9c24e2491e2b8b15303a9ce
Source noteValidation data from https://doi.org/10.1039/C8SC04228D