Citric Acid → 4-(3-Fluorophenoxy)thiophene-2-carbaldehyde

HRID 957656Notes

Reaction equation

HRID 957656 reaction equation
[C:32](=[O:33])([OH:34])[O-:35].[CH3:37][OH:38].[F:1][c:2]1[cH:3][c:4]([O:5][c:6]2[cH:7][c:8]([CH:11]3[O:12][CH2:15][CH2:14][O:13]3)[s:9][cH:10]2)[cH:16][cH:17][cH:18]1.[Na+:36].[OH:19][C:20]([CH2:21][C:22]([C:23](=[O:24])[OH:25])([CH2:26][C:27](=[O:28])[OH:29])[OH:30])=[O:31]>>[F:1][c:2]1[cH:3][c:4]([O:5][c:6]2[cH:7][c:8]([CH:11]=[O:12])[s:9][cH:10]2)[cH:16][cH:17][cH:18]1

Participants

6

Reactant 5

HCID 311Citric AcidHCID 769Bicarbonate IonHCID 887MethanolHCID 923Sodium ionHCID 231305304-(3-Fluoro-phenoxy)-thiophen-2-yl-[1,3]dioxolane

Product 1

HCID 231306054-(3-Fluorophenoxy)thiophene-2-carbaldehyde

Sources & evidence

ORD record
ord-1db5e325f3e84f17b061d96b1eec02ea
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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