5-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-2-methoxybenzenesulfonamide → 5-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-N-(2-hydroxy-1,1-dimethyl-ethyl)-2-methoxy-benzenesulfonamide

HRID 95776Notes

Reaction equation

HRID 95776 reaction equation
[Br:22][c:23]1[cH:24][cH:25][c:26]([O:38][CH3:39])[c:27]([S:29](=[O:30])(=[O:31])[NH:32][C:33]([CH2:34][OH:35])([CH3:36])[CH3:37])[cH:28]1.[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]4[CH2:15][CH2:16]4)[cH:13]2)[n:17][cH:18][c:19]3[C:20]#[CH:21])[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][c:10]3[n:11]([c:12]([CH:14]4[CH2:15][CH2:16]4)[cH:13]2)[n:17][cH:18][c:19]3[C:20]#[C:21][c:23]2[cH:24][cH:25][c:26]([O:38][CH3:39])[c:27]([S:29](=[O:30])(=[O:31])[NH:32][C:33]([CH2:34][OH:35])([CH3:36])[CH3:37])[cH:28]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 275180375-bromo-N-(1-hydroxy-2-methylpropan-2-yl)-2-methoxybenzenesulfonamideHCID 866079965-(4-Chloro-phenyl)-7-cyclopropyl-3-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 118516195-[5-(4-Chloro-phenyl)-7-cyclopropyl-pyrazolo[1,5-a]pyrimidin-3-ylethynyl]-N-(2-hydroxy-1,1-dimethyl-ethyl)-2-methoxy-benzenesulfonamide

Sources & evidence

ORD record
ord-1a26bb8229a348c7883782e51fae4336
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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