5-Amino-1-cyclopropyl-6,7-difluoro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylic acid → 5-Amino-1-cyclopropyl-7-[3-[(cyclopropylamino)methyl]-4-fluoropyrrolidin-1-yl]-6-fluoro-8-methyl-4-oxoquinoline-3-carboxylic acid
Reaction equation
[CH:22]1([NH:25][CH2:26][CH:27]2[CH2:28][NH:29][CH2:30][CH:31]2[F:32])[CH2:23][CH2:24]1.[NH2:1][c:2]1[c:3]2[c:4](=[O:21])[c:5]([C:18](=[O:19])[OH:20])[cH:6][n:7]([CH:15]3[CH2:16][CH2:17]3)[c:8]2[c:9]([CH3:14])[c:10]([F:13])[c:11]1[F:12]>>[NH2:1][c:2]1[c:3]2[c:4](=[O:21])[c:5]([C:18](=[O:19])[OH:20])[cH:6][n:7]([CH:15]3[CH2:16][CH2:17]3)[c:8]2[c:9]([CH3:14])[c:10]([N:29]2[CH2:28][CH:27]([CH2:26][NH:25][CH:22]3[CH2:23][CH2:24]3)[CH:31]([F:32])[CH2:30]2)[c:11]1[F:12]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-9a98c3444049489993c5a741ef9f2d0f
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
Loading…