Bicarbonate Ion → cyclopropanecarboxylic acid [4-(3-cyano-1-ethyl-6-hydroxy-1H-indol-2-yl)-phenyl]-amide

HRID 957861Notes

Reaction equation

HRID 957861 reaction equation
[B:29]([Br:30])([Br:31])[Br:32].[C:1](#[N:2])[c:3]1[c:4](-[c:17]2[cH:18][cH:19][c:20]([NH:23][C:24](=[O:25])[CH:26]3[CH2:27][CH2:28]3)[cH:21][cH:22]2)[n:5]([CH2:15][CH3:16])[c:6]2[cH:7][c:8]([O:12][CH2:13][CH3:14])[cH:9][cH:10][c:11]12.[Cl:38][CH2:39][Cl:40].[Na+:37].[O-:33][C:34]([OH:35])=[O:36]>>[C:1](#[N:2])[c:3]1[c:4](-[c:17]2[cH:18][cH:19][c:20]([NH:23][C:24](=[O:25])[CH:26]3[CH2:27][CH2:28]3)[cH:21][cH:22]2)[n:5]([CH2:15][CH3:16])[c:6]2[cH:7][c:8]([OH:12])[cH:9][cH:10][c:11]12

Participants

6

Reactant 5

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6344DichloromethaneHCID 25134Boron tribromideHCID 25052168N-[4-(3-cyano-6-ethoxy-1-ethyl-indol-2-yl)phenyl]cyclopropanecarboxamide

Product 1

HCID 59425200cyclopropanecarboxylic acid [4-(3-cyano-1-ethyl-6-hydroxy-1H-indol-2-yl)-phenyl]-amide

Sources & evidence

ORD record
ord-e8f00ff26b5f4f6b80d9be7c19742239
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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