Methanol → Cyclopropyl-{4-[(3,5-dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester

HRID 958365Notes

Reaction equation

HRID 958365 reaction equation
[BH4-:27].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([N:7]([CH:8]1[CH2:9][CH2:10]1)[CH2:11][CH2:12][CH2:13][CH2:14][NH2:15])=[O:16].[CH3:17][c:18]1[c:19]([CH:25]=[O:26])[n:20][cH:21][c:22]([CH3:24])[cH:23]1.[CH3:29][OH:30].[Na+:28]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6]([N:7]([CH:8]1[CH2:9][CH2:10]1)[CH2:11][CH2:12][CH2:13][CH2:14][NH:15][CH2:25][c:19]1[c:18]([CH3:17])[cH:23][c:22]([CH3:24])[cH:21][n:20]1)=[O:16]

Participants

6

Reactant 5

HCID 887MethanolHCID 923Sodium ionHCID 28123BorohydrideHCID 187316833,5-Dimethylpyridine-2-carbaldehydeHCID 67271617(4-Amino-butyl)-cyclopropylcarbamic acid tert-butyl ester

Product 1

HCID 67272811Cyclopropyl-{4-[(3,5-dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester

Sources & evidence

ORD record
ord-ca8d976751c0473aa2ffc7903bab2238
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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