Ethyl 1-amino-2-vinylcyclopropanecarboxylate → 2-(1-Ethoxycarbonyl-2-vinyl-cyclopropylcarbamoyl)-4-[2-(2-isopropylamino-thiazol-4-yl)-7-methoxy-quinolin-4-yloxy]-pyrrolidine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:35](=[O:36])[OH:37])[CH2:10][CH:11]([O:13][c:14]2[cH:15][c:16](-[c:26]3[n:27][c:28]([NH:31][CH:32]([CH3:33])[CH3:34])[s:29][cH:30]3)[n:17][c:18]3[cH:19][c:20]([O:24][CH3:25])[cH:21][cH:22][c:23]23)[CH2:12]1.[CH2:38]([CH3:39])[O:40][C:41](=[O:42])[C:43]1([NH2:48])[CH:44]([CH:46]=[CH2:47])[CH2:45]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:35](=[O:37])[NH:48][C:43]2([C:41]([O:40][CH2:38][CH3:39])=[O:42])[CH:44]([CH:46]=[CH2:47])[CH2:45]2)[CH2:10][CH:11]([O:13][c:14]2[cH:15][c:16](-[c:26]3[n:27][c:28]([NH:31][CH:32]([CH3:33])[CH3:34])[s:29][cH:30]3)[n:17][c:18]3[cH:19][c:20]([O:24][CH3:25])[cH:21][cH:22][c:23]23)[CH2:12]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-da94b51ad4834f668dea5010d52748d7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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