3,5-Difluorobenzoyl chloride → 5-Bromo-1'-[{6-chloro-1-(3,5-difluorobenzoyl)-1H-indol-3-yl]carbonyl}-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:27][cH:28]1)[C:6]1([O:7][C:8]2=[O:9])[CH2:10][CH2:11][N:12]([C:15](=[O:16])[c:17]2[cH:18][nH:19][c:20]3[cH:21][c:22]([Cl:26])[cH:23][cH:24][c:25]23)[CH2:13][CH2:14]1.[F:29][c:30]1[cH:31][c:32]([C:33](=[O:34])[Cl:35])[cH:36][c:37]([F:39])[cH:38]1>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([cH:27][cH:28]1)[C:6]1([O:7][C:8]2=[O:9])[CH2:10][CH2:11][N:12]([C:15](=[O:16])[c:17]2[cH:18][n:19]([C:33]([c:32]3[cH:31][c:30]([F:29])[cH:38][c:37]([F:39])[cH:36]3)=[O:34])[c:20]3[cH:21][c:22]([Cl:26])[cH:23][cH:24][c:25]23)[CH2:13][CH2:14]1Participants
3
Sources & evidence
- ORD record
- ord-8ca1002a064c41f9bc9f47ce5d043753
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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