4-(bromomethyl)-3-methyl-5-phenylisoxazole → tert-butyl [5-chloro-1'-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-2,5'-dioxospiro[indole-3,3'-pyrrolidin]-1(2H)-yl]acetate

HRID 959323Notes

Reaction equation

HRID 959323 reaction equation
[Br:33][CH2:34][c:35]1[c:36]([CH3:46])[n:37][o:38][c:39]1-[c:40]1[cH:41][cH:42][cH:43][cH:44][cH:45]1.[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([CH2:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[C:6](=[O:19])[C:5]21[CH2:20][N:21]([CH2:25][c:26]2[cH:27][cH:28][cH:29][cH:30][c:31]2[F:32])[C:22](=[O:24])[CH2:23]1>>[Cl:1][c:2]1[cH:3][c:4]2[c:8]([cH:9][cH:10]1)[N:7]([CH2:11][C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[C:6](=[O:19])[C:5]21[CH2:20][N:21]([CH2:25][c:35]2[c:36]([CH3:46])[n:37][o:38][c:39]2-[c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[C:22](=[O:24])[CH2:23]1

Participants

3

Reactant 2

HCID 27765184-(bromomethyl)-3-methyl-5-phenylisoxazoleHCID 58017127tert-butyl [5-chloro-1'-(2-fluorobenzyl)-2,5'-dioxospiro[indole-3,3'-pyrrolidin]-1(2H)-yl]acetate

Product 1

HCID 24827316tert-butyl [5-chloro-1'-[(3-methyl-5-phenylisoxazol-4-yl)methyl]-2,5'-dioxospiro[indole-3,3'-pyrrolidin]-1(2H)-yl]acetate

Sources & evidence

ORD record
ord-975886b477a3420c9185a1ee8ba5c631
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…