Dichloromethane → Methyl 3-{[(2,5-difluorophenyl)sulfonyl]amino}benzoate

HRID 959604Notes

Reaction equation

HRID 959604 reaction equation
[Cl:1][c:2]1[n:3][c:4]([CH:5]=[C:6]([c:7]2[cH:8][c:9]([NH:10][S:11]([c:12]3[c:13]([F:14])[cH:15][cH:16][cH:17][c:18]3[F:19])(=[O:20])=[O:21])[cH:22][cH:23][cH:24]2)[OH:25])[cH:26][cH:27][n:28]1.[Cl:52][CH2:53][Cl:54].[F:40][c:41]1[c:42]([S:48](=[O:49])(=[O:50])[Cl:51])[cH:43][c:44]([F:47])[cH:45][cH:46]1.[NH2:29][c:30]1[cH:31][c:32]([C:33](=[O:34])[O:35][CH3:36])[cH:37][cH:38][cH:39]1>>[NH:29]([c:30]1[cH:31][c:32]([C:33](=[O:34])[O:35][CH3:36])[cH:37][cH:38][cH:39]1)[S:48]([c:42]1[c:41]([F:40])[cH:46][cH:45][c:44]([F:47])[cH:43]1)(=[O:49])=[O:50]

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 78274Benzoic acid, 3-amino-, methyl esterHCID 27369112,5-Difluorobenzenesulfonyl chlorideHCID 154041434N-[3-[2-(2-chloropyrimidin-4-yl)-1-hydroxyethenyl]phenyl]-2,6-difluorobenzenesulfonamide

Product 1

HCID 16344470Methyl 3-{[(2,5-difluorophenyl)sulfonyl]amino}benzoate

Sources & evidence

ORD record
ord-c460c20bc65342108512d00cf967966b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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