tert-Butyl bromoacetate → N4-(3-aminophenyl)-N2-(3-tert-butoxycarbonylmethyleneaminophenyl)-5-fluoro-2,4-pyrimidinediamine
Reaction equation
[Br:24][CH2:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32].[NH2:1][c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][cH:11][c:12]([F:23])[c:13]([NH:15][c:16]3[cH:17][c:18]([NH2:22])[cH:19][cH:20][cH:21]3)[n:14]2)[cH:5][cH:6][cH:7]1>>[N:1]([c:2]1[cH:3][c:4]([NH:8][c:9]2[n:10][cH:11][c:12]([F:23])[c:13]([NH:15][c:16]3[cH:17][c:18]([NH2:22])[cH:19][cH:20][cH:21]3)[n:14]2)[cH:5][cH:6][cH:7]1)=[CH:25][C:26](=[O:27])[O:28][C:29]([CH3:30])([CH3:31])[CH3:32]Participants
3
Sources & evidence
- ORD record
- ord-03f0b2320dda4a1f9d0160321a413cf5
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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