3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde → 4-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-2-isobutyl-piperazine-1-carboxylic acid tert-butyl ester
Reaction equation
[C:16]([CH3:17])([CH3:18])([CH3:19])[O:20][C:21](=[O:22])[N:23]1[CH:24]([CH2:29][CH:30]([CH3:31])[CH3:32])[CH2:25][NH:26][CH2:27][CH2:28]1.[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[cH:9][c:10]([CH:11]=[O:12])[cH:13][cH:14][cH:15]2)[n:7]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[cH:9][c:10]([CH2:11][N:26]3[CH2:25][CH:24]([CH2:29][CH:30]([CH3:31])[CH3:32])[N:23]([C:21]([O:20][C:16]([CH3:17])([CH3:18])[CH3:19])=[O:22])[CH2:28][CH2:27]3)[cH:13][cH:14][cH:15]2)[n:7]1Participants
3
Sources & evidence
- ORD record
- ord-9843b2d6fb7b4fbc9265afb4c9f8a885
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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