6-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazine → Ethyl 3-[4-[[4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]methyl]phenyl]prop-2-enoate

HRID 960250Notes

Reaction equation

HRID 960250 reaction equation
[CH:1](=[O:2])[c:3]1[cH:4][cH:5][c:6]([CH:9]=[CH:10][C:11](=[O:12])[O:13][CH2:14][CH3:15])[cH:7][cH:8]1.[N:16]1([c:22]2[cH:23][cH:24][c:25]3[n:26]([n:27]2)[c:28]([C:31]([F:32])([F:33])[F:34])[n:29][n:30]3)[CH2:17][CH2:18][NH:19][CH2:20][CH2:21]1>>[CH2:1]([c:3]1[cH:4][cH:5][c:6]([CH:9]=[CH:10][C:11](=[O:12])[O:13][CH2:14][CH3:15])[cH:7][cH:8]1)[N:19]1[CH2:18][CH2:17][N:16]([c:22]2[cH:23][cH:24][c:25]3[n:26]([n:27]2)[c:28]([C:31]([F:32])([F:33])[F:34])[n:29][n:30]3)[CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 14768626-Piperazino-3-(trifluoromethyl)[1,2,4]triazolo[4,3-b]pyridazineHCID 534066763-(4-Formylphenyl)-2-propenoic acid ethyl ester

Product 1

HCID 59149817Ethyl 3-[4-[[4-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperazin-1-yl]methyl]phenyl]prop-2-enoate

Sources & evidence

ORD record
ord-aa05f43d6fb84a3a86ab5ecba65d1736
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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