Ethanol → (6-Chloro-2-methoxy-pyrimidin-4-yl)-[2-(3,4-difluoro-phenyl)-ethyl]-amine

HRID 960534Notes

Reaction equation

HRID 960534 reaction equation
[CH3:23][CH2:24][OH:25].[Cl:1][c:2]1[n:3][c:4]([O:9][CH3:10])[n:5][c:6]([Cl:8])[cH:7]1.[F:11][c:12]1[cH:13][c:14]([CH2:19][CH2:20][NH2:21])[cH:15][cH:16][c:17]1[F:18].[OH2:22]>>[c:2]1([NH:21][CH2:20][CH2:19][c:14]2[cH:13][c:12]([F:11])[c:17]([F:18])[cH:16][cH:15]2)[n:3][c:4]([O:9][CH3:10])[n:5][c:6]([Cl:8])[cH:7]1

Participants

5

Reactant 4

HCID 702EthanolHCID 962WaterHCID 34669162-(3,4-Difluorophenyl)ethanamineHCID 120521604,6-Dichloro-2-methoxypyrimidine

Product 1

HCID 86240123(6-Chloro-2-methoxy-pyrimidin-4-yl)-[2-(3,4-difluoro-phenyl)-ethyl]-amine

Sources & evidence

ORD record
ord-ac531d140e43474980e5318f7268afce
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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