1-[2-(4-Azido-3-hydroxypiperidin-1-yl)ethyl]-5,7-difluoroquinolin-2-one → 1-[2-(4-Amino-3-hydroxypiperidin-1-yl)ethyl]-5,7-difluoroquinolin-2-one
Reaction equation
[N:1](=[N+:2]=[N-:3])[CH:4]1[CH:5]([OH:25])[CH2:6][N:7]([CH2:10][CH2:11][n:12]2[c:13](=[O:24])[cH:14][cH:15][c:16]3[c:17]([F:23])[cH:18][c:19]([F:22])[cH:20][c:21]23)[CH2:8][CH2:9]1.[NH2:26][CH:27]1[CH2:28][CH2:29][N:30]([CH2:31][CH2:32][n:33]2[c:34]3[c:35]([c:36]([F:37])[cH:38][c:39]([F:40])[cH:41]3)[cH:42][cH:43][c:44]2=[O:45])[CH2:46][CH:47]1[C:48]([O:49][CH3:50])=[O:51]>>[NH2:1][CH:4]1[CH:5]([OH:25])[CH2:6][N:7]([CH2:10][CH2:11][n:12]2[c:13](=[O:24])[cH:14][cH:15][c:16]3[c:17]([F:23])[cH:18][c:19]([F:22])[cH:20][c:21]23)[CH2:8][CH2:9]1Participants
3
Sources & evidence
- ORD record
- ord-a8e9e8ab4a67418ba53c43b0dfaef6c9
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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