Dichloromethane → 4-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

HRID 960739Notes

Reaction equation

HRID 960739 reaction equation
[C:11]([CH3:12])([CH3:13])([CH3:14])[O:15][C:16](=[O:17])[N:18]1[CH2:19][CH2:20][CH:21]([NH2:24])[CH2:22][CH2:23]1.[Cl:1][c:2]1[cH:3][c:4]([CH3:10])[c:5]([CH:8]=[O:9])[n:6][cH:7]1.[Cl:25][CH2:26][Cl:27]>>[Cl:1][c:2]1[cH:3][c:4]([CH3:10])[c:5]([CH2:8][NH:24][CH:21]2[CH2:20][CH2:19][N:18]([C:16]([O:15][C:11]([CH3:12])([CH3:13])[CH3:14])=[O:17])[CH2:23][CH2:22]2)[n:6][cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 12682914-Amino-1-Boc-piperidineHCID 722140555-Chloro-3-methylpicolinaldehyde

Product 1

HCID 672718274-[(5-Chloro-3-methyl-pyridin-2-ylmethyl)-amino]-piperidine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-db6e57ae30b04ac48d7c73cd872bda63
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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