{1-[5-(4'-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-ylmethyl]-2-oxo-piperidin-3-yl]-carbamic acid tert-butyl ester → 3'-(2-Methoxycarbonylamino-3-methyl-butyryl)-4-[4-(4-{2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl}-phenylethynyl)-phenyl]-1-(2-trimethylsilanyl-ethoxymethyl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazole

HRID 961114Notes

Reaction equation

HRID 961114 reaction equation
[C:1]([O:2][C:3](=[O:4])[N:8]1[CH2:9][N:10]([C:69]([CH:70]([CH:71]([CH3:72])[CH3:73])[NH:74][C:75](=[O:76])[O:77][CH3:78])=[O:79])[CH:11]([c:13]2[n:14]([CH2:61][O:62][CH2:63][CH2:64][Si:65]([CH3:66])([CH3:67])[CH3:68])[cH:15][c:16](-[c:18]3[cH:19][cH:20][c:21]([C:24]#[C:25][c:26]4[cH:27][cH:28][c:29](-[c:32]5[n:33][c:34]([CH:45]6[N:46]([C:50]([CH:51]([CH:52]([CH3:53])[CH3:54])[NH:55][C:56](=[O:57])[O:58][CH3:59])=[O:60])[CH2:47][CH2:48][CH2:49]6)[n:35]([CH2:37][O:38][CH2:39][CH2:40][Si:41]([CH3:42])([CH3:43])[CH3:44])[cH:36]5)[cH:30][cH:31]4)[cH:22][cH:23]3)[n:17]2)[CH2:12]1)([CH3:5])([CH3:6])[CH3:7].[C:80]([O:81][C:82](=[O:83])[NH:84][CH:85]1[CH2:86][CH2:87][CH2:88][N:89]([CH2:90][c:91]2[nH:92][c:93](-[c:94]3[cH:95][cH:96][c:97](-[c:98]4[cH:99][cH:100][c:101](-[c:102]5[nH:103][c:104]([CH:105]6[CH2:106][CH2:107][CH2:108][N:109]6[C:110](=[O:111])[CH:112]([NH:113][C:114]([O:115][CH3:116])=[O:117])[CH:118]([CH3:119])[CH3:120])[n:121][cH:122]5)[cH:123][cH:124]4)[cH:125][cH:126]3)[cH:127][n:128]2)[C:129]1=[O:130])([CH3:131])([CH3:132])[CH3:133]>>[NH:8]1[CH2:9][N:10]([C:69]([CH:70]([CH:71]([CH3:72])[CH3:73])[NH:74][C:75](=[O:76])[O:77][CH3:78])=[O:79])[CH:11]([c:13]2[n:14]([CH2:61][O:62][CH2:63][CH2:64][Si:65]([CH3:66])([CH3:67])[CH3:68])[cH:15][c:16](-[c:18]3[cH:19][cH:20][c:21]([C:24]#[C:25][c:26]4[cH:27][cH:28][c:29](-[c:32]5[n:33][c:34]([CH:45]6[N:46]([C:50]([CH:51]([CH:52]([CH3:53])[CH3:54])[NH:55][C:56](=[O:57])[O:58][CH3:59])=[O:60])[CH2:47][CH2:48][CH2:49]6)[n:35]([CH2:37][O:38][CH2:39][CH2:40][Si:41]([CH3:42])([CH3:43])[CH3:44])[cH:36]5)[cH:30][cH:31]4)[cH:22][cH:23]3)[n:17]2)[CH2:12]1

Participants

3

Reactant 2

HCID 66620320{1-[5-(4'-{2-[1-(2-Methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-biphenyl-4-yl)-1H-imidazol-2-ylmethyl]-2-oxo-piperidin-3-yl]-carbamic acid tert-butyl esterHCID 866488803'-(2-methoxycarbonylamino-3-methyl-butyryl)-4-[4-(4-{2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl}-phenylethynyl)-phenyl]-1-(2-trimethylsilanyl-ethoxymethyl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazolyl-1'-carboxylic acid tert-butyl ester

Product 1

HCID 866488813'-(2-Methoxycarbonylamino-3-methyl-butyryl)-4-[4-(4-{2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-4-yl}-phenylethynyl)-phenyl]-1-(2-trimethylsilanyl-ethoxymethyl)-2',3',4',5'-tetrahydro-1H-[2,4']biimidazole

Sources & evidence

ORD record
ord-4adf221b87194962ad493cfb0399c654
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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