4-bromo-2,3-dihydro-1H-indol-2-one → 2-(4-bromo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-pyrrolidin-1-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one

HRID 961172Notes

Reaction equation

HRID 961172 reaction equation
[Br:22][c:23]1[c:24]2[c:28]([cH:29][cH:30][cH:31]1)[NH:27][C:26](=[O:32])[CH2:25]2.[CH3:1][c:2]1[c:3]([CH:20]=[O:21])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10][CH2:11]2>>[CH3:1][c:2]1[c:3]([CH:20]=[C:25]2[c:24]3[c:23]([Br:22])[cH:31][cH:30][cH:29][c:28]3[NH:27][C:26]2=[O:32])[nH:4][c:5]2[c:6]1[C:7](=[O:19])[N:8]([CH2:12][CH2:13][N:14]1[CH2:15][CH2:16][CH2:17][CH2:18]1)[CH2:9][CH2:10][CH2:11]2

Participants

3

Reactant 2

HCID 27631904-bromo-2,3-dihydro-1H-indol-2-oneHCID 592500963-Methyl-4-oxo-5-(2-pyrrolidin-1-yl-ethyl)-1,4,5,6,7,8-hexahydro-pyrrolo[3,2-c]azepine-2-carbaldehyde

Product 1

HCID 685278022-(4-bromo-2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-3-methyl-5-(2-pyrrolidin-1-yl-ethyl)-5,6,7,8-tetrahydro-1H-pyrrolo[3,2-c]azepin-4-one

Sources & evidence

ORD record
ord-c5e8513772b741258282dedb7aa5cdbf
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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