3-Chloropyridine-2-carbonitrile → 3-(4-Hydroxyphenyl)pyridine-2-carbonitrile
Reaction equation
[CH3:69][C:70]1([CH3:71])[C:72]([CH3:73])([CH3:74])[O:75][B:76]([c:77]2[cH:78][cH:79][c:80]([OH:83])[cH:81][cH:82]2)[O:84]1.[Cl:60][c:61]1[c:62]([C:67]#[N:68])[n:63][cH:64][cH:65][cH:66]1.[OH:49][CH2:50][c:51]1[cH:52][cH:53][c:54]([B:55]([OH:56])[OH:57])[cH:58][cH:59]1.[s:1]1[c:2]2[cH:3][cH:4][cH:5][cH:6][c:7]2[n:8][c:9]1[N:10]([CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:16])([CH3:17])[CH3:18])[C:19]([c:20]1[cH:21][cH:22][cH:23][c:24]2[c:25]1[CH2:26][N:27]([c:28]1[s:29][c:30](-[c:31]3[cH:32][cH:33][c:34]([CH2:35][OH:36])[cH:37][cH:38]3)[c:39]([C:40]([O:41][CH2:42][CH3:43])=[O:44])[n:45]1)[CH2:46][CH2:47]2)=[O:48]>>[c:61]1(-[c:77]2[cH:78][cH:79][c:80]([OH:83])[cH:81][cH:82]2)[c:62]([C:67]#[N:68])[n:63][cH:64][cH:65][cH:66]1Participants
5
Reactant 4
HCID 8182583-Chloropyridine-2-carbonitrile
HCID 27346244-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
HCID 27347064-(Hydroxymethyl)benzeneboronic acid
HCID 59447480ethyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-(hydroxymethyl)phenyl)thiazole-4-carboxylateProduct 1
Sources & evidence
- ORD record
- ord-2436bc9846474617b38d1aeacd9a16e8
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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