[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetic acid → 2-[3-(2-{2-[4-Cyclopropyl-2-(4-trifluoromethyl-phenyl)-pyrimidin-5-yl]-acetylamino}-ethyl)-5-methoxy-phenoxy]-2-methyl-propionic acid ethyl ester
Reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([C:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][c:11]([CH2:17][CH2:18][NH2:19])[cH:12][c:13]([O:15][CH3:16])[cH:14]1)=[O:20].[CH:21]1([c:24]2[n:25][c:26](-[c:34]3[cH:35][cH:36][c:37]([C:40]([F:41])([F:42])[F:43])[cH:38][cH:39]3)[n:27][cH:28][c:29]2[CH2:30][C:31](=[O:32])[OH:33])[CH2:22][CH2:23]1.[Cl:44][CH2:45][c:46]1[c:47]([CH:48]2[CH2:49][CH2:50]2)[n:51][c:52](-[c:53]2[cH:54][cH:55][c:56]([C:57]([F:58])([F:59])[F:60])[cH:61][cH:62]2)[n:63][cH:64]1>>[CH2:1]([CH3:2])[O:3][C:4]([C:5]([CH3:6])([CH3:7])[O:8][c:9]1[cH:10][c:11]([CH2:17][CH2:18][NH:19][C:31]([CH2:30][c:29]2[c:24]([CH:21]3[CH2:22][CH2:23]3)[n:25][c:26](-[c:34]3[cH:35][cH:36][c:37]([C:40]([F:41])([F:42])[F:43])[cH:38][cH:39]3)[n:27][cH:28]2)=[O:32])[cH:12][c:13]([O:15][CH3:16])[cH:14]1)=[O:20]Participants
4
Reactant 3
Product 1
Sources & evidence
- ORD record
- ord-bdd6e060c427434b88e38b8258957d87
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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