2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-oxonaphthalen-7-yl)-4-pyrimidineamine → 2-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-hydroxynaphthalen-7-yl)-4-pyrimidineamine

HRID 961689Notes

Reaction equation

HRID 961689 reaction equation
[CH2:1]1[CH2:2][O:3][C:4]2([NH2:5])[N:6]([C:7]([NH:8][c:9]3[cH:10][cH:11][c:12]4[o:13][c:14]([CH2:15][OH:16])[cH:17][c:18]4[cH:19]3)=[N:20][CH:21]=[C:22]2[F:23])[O:24]1.[Cl:25][c:26]1[n:27][cH:28][c:29]([F:44])[c:30]([NH:32][c:33]2[cH:34][cH:35][c:36]3[c:41]([cH:42]2)[C:40](=[O:43])[CH2:39][CH2:38][CH2:37]3)[n:31]1>>[Cl:25][c:26]1[n:27][cH:28][c:29]([F:44])[c:30]([NH:32][c:33]2[cH:34][cH:35][c:36]3[c:41]([cH:42]2)[CH:40]([OH:43])[CH2:39][CH2:38][CH2:37]3)[n:31]1

Participants

3

Reactant 2

HCID 220607872-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-oxonaphthalen-7-yl)-4-pyrimidineamineHCID 66759177N4-(3,4-ethylenedioxy)-5-fluoro-N2-[2-(hydroxymethyl)benzofuran-5-yl]-2,4-pyrimidinediamine

Product 1

HCID 220608542-chloro-5-fluoro-N4-(1,2,3,4-tetrahydro-1-hydroxynaphthalen-7-yl)-4-pyrimidineamine

Sources & evidence

ORD record
ord-ca3d7c1d4b0f497f96501cf7c47338f9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…