Acetonitrile → (4-{7-[Bis-(2-trimethylsilanyl-ethoxymethyl)-amino]-6-bromo-3-quinolin-3-yl-pyrazolo[1,5-a]pyrimidin-5-yl}-cyclohexyl)-acetic acid ethyl ester
Reaction equation
[Br:49][N:50]1[C:51](=[O:52])[CH2:53][CH2:54][C:55]1=[O:56].[CH3:1][Si:2]([CH2:3][CH2:4][O:5][CH2:6][N:7]([c:8]1[cH:9][c:10]([CH:27]2[CH2:28][CH2:29][CH:30]([CH2:33][C:34](=[O:35])[O:36][CH2:37][CH3:38])[CH2:31][CH2:32]2)[n:11][c:12]2[n:13]1[n:14][cH:15][c:16]2-[c:17]1[cH:18][n:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[cH:26]1)[CH2:39][O:40][CH2:41][CH2:42][Si:43]([CH3:44])([CH3:45])[CH3:46])([CH3:47])[CH3:48].[CH3:57][C:58]#[N:59]>>[CH3:1][Si:2]([CH2:3][CH2:4][O:5][CH2:6][N:7]([c:8]1[c:9]([Br:49])[c:10]([CH:27]2[CH2:28][CH2:29][CH:30]([CH2:33][C:34](=[O:35])[O:36][CH2:37][CH3:38])[CH2:31][CH2:32]2)[n:11][c:12]2[n:13]1[n:14][cH:15][c:16]2-[c:17]1[cH:18][n:19][c:20]2[cH:21][cH:22][cH:23][cH:24][c:25]2[cH:26]1)[CH2:39][O:40][CH2:41][CH2:42][Si:43]([CH3:44])([CH3:45])[CH3:46])([CH3:47])[CH3:48]Participants
4
Sources & evidence
- ORD record
- ord-b0d61e58c10045858f2f23cd2ba60553
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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