Propane, 1-bromo-3-fluoro- → 2-[1-(3,4-dimethoxy-benzyl)-5-(3-fluoro-propoxy)-8-methoxy-3,4-dihydro-1H-isoquinolin-2-yl]-N-(pyridin-2-yl-methyl)-acetamide
Reaction equation
[Br:36][CH2:37][CH2:38][CH2:39][F:40].[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:6][CH:7]2[N:8]([CH2:20][C:21](=[O:22])[NH:23][CH2:24][c:25]3[n:26][cH:27][cH:28][cH:29][cH:30]3)[CH2:9][CH2:10][c:11]3[c:12]([OH:19])[cH:13][cH:14][c:15]([O:17][CH3:18])[c:16]32)[cH:31][cH:32][c:33]1[O:34][CH3:35]>>[CH3:1][O:2][c:3]1[cH:4][c:5]([CH2:6][CH:7]2[N:8]([CH2:20][C:21](=[O:22])[NH:23][CH2:24][c:25]3[n:26][cH:27][cH:28][cH:29][cH:30]3)[CH2:9][CH2:10][c:11]3[c:12]([O:19][CH2:37][CH2:38][CH2:39][F:40])[cH:13][cH:14][c:15]([O:17][CH3:18])[c:16]32)[cH:31][cH:32][c:33]1[O:34][CH3:35]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-0f263e05f08143dfb24d94498835e131
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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