Benzylamine → 5-Amino-1-(4-fluorophenyl)-N-(3,3,3-trifluoro-2-hydroxy-2-{[(phenylmethyl)amino]methyl}propyl)-1H-pyrazole-4-carboxamide

HRID 961971Notes

Reaction equation

HRID 961971 reaction equation
[NH2:1][c:2]1[c:3]([C:14](=[O:15])[NH:16][CH2:17][C:18]2([C:21]([F:22])([F:23])[F:24])[O:19][CH2:20]2)[cH:4][n:5][n:6]1-[c:7]1[cH:8][cH:9][c:10]([F:13])[cH:11][cH:12]1.[NH2:25][CH2:26][c:27]1[cH:28][cH:29][cH:30][cH:31][cH:32]1.[O:33]1[CH2:34][CH2:35][O:36][CH2:37][CH2:38]1>>[NH2:1][c:2]1[c:3]([C:14](=[O:15])[NH:16][CH2:17][C:18]([OH:19])([CH2:20][NH:25][CH2:26][c:27]2[cH:28][cH:29][cH:30][cH:31][cH:32]2)[C:21]([F:22])([F:23])[F:24])[cH:4][n:5][n:6]1-[c:7]1[cH:8][cH:9][c:10]([F:13])[cH:11][cH:12]1

Participants

4

Reactant 3

HCID 7504BenzylamineHCID 312751,4-DioxaneHCID 594874985-amino-1-(4-fluorophenyl)-N-{[2-(trifluoromethyl)-2-oxiranyl]methyl}-1H-pyrazole-4-carboxamide

Product 1

HCID 594874975-Amino-1-(4-fluorophenyl)-N-(3,3,3-trifluoro-2-hydroxy-2-{[(phenylmethyl)amino]methyl}propyl)-1H-pyrazole-4-carboxamide

Sources & evidence

ORD record
ord-7156eee3ad644e9d8d8eafd4d0d62e4f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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