Acetate → 5-(3,5-Difluorophenyl)-2,3-difluoropyridine

HRID 962269Notes

Reaction equation

HRID 962269 reaction equation
[CH2:29]1[O:30][CH2:31][CH2:32][O:33][CH2:34]1.[Cl:20][c:21]1[cH:22][c:23]([F:28])[c:24]([F:27])[n:25][cH:26]1.[F:9][c:10]1[cH:11][c:12]([B:17]([OH:18])[OH:19])[cH:13][c:14]([F:16])[cH:15]1.[K+:6].[K+:7].[K+:8].[O-:37][C:38]([CH3:39])=[O:40].[O-:41][C:42]([CH3:43])=[O:44].[OH2:35].[P:1]([O-:2])([O-:3])([O-:4])=[O:5].[Pd+2:36]>>[F:9][c:10]1[cH:11][c:12](-[c:21]2[cH:22][c:23]([F:28])[c:24]([F:27])[n:25][cH:26]2)[cH:13][c:14]([F:16])[cH:15]1

Participants

9

Reactant 8

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 962WaterHCID 1061PhosphateHCID 312751,4-DioxaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2734338(3,5-Difluorophenyl)boronic acidHCID 27832485-Chloro-2,3-difluoropyridine

Product 1

HCID 675027115-(3,5-Difluorophenyl)-2,3-difluoropyridine

Sources & evidence

ORD record
ord-b966ea59f4de4d95bbac1684185fa302
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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