HCID 53703705, compound → HCID 19083664, compound

HRID 962356Notes

Reaction equation

HRID 962356 reaction equation
[CH:1]1([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH:13]=[CH:14][C:15]2[CH:16]=[N:17][C:18]([C:21]3[CH:26]=[CH:25][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:23][CH:22]=3)=[N:19][CH:20]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[H][H]>C1(C)C=CC=CC=1.[Pd]>[CH:1]1([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]2[CH:16]=[N:17][C:18]([C:21]3[CH:22]=[CH:23][C:24]([O:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])=[CH:25][CH:26]=3)=[N:19][CH:20]=2)[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

5

Reactant 2

HCID 53703705HCID 53703705, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19083664HCID 19083664, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 1140TolueneSolvent

Procedure

A solution of 1.86 g of 5-(9-cyclopentyl-non-1-enyl)-2-(4-heptyloxy-phenyl)-pyrimidine in 35 ml of toluene is hydrogenated with 0.24 g of 5% palladium/charcoal at room temperature and normal pressure until the hydrogen uptake comes to a standstill. Recrystallization from ethanol of the crude product obtained after filtration and concentration of the filtrate yields pure 5-(9-cyclopentyl-nonyl)-2-(4-heptyloxy-phenyl)-pyrimidine.

Workup

  1. customRecrystallization from ethanol of the crude product
  2. customobtained
  3. filtrationafter filtration and concentration of the filtrate

Sources & evidence

ORD record
ord-18ec0de0949f4af49f56e59dd3c56951
Source dataset
uspto-grants-1998_06
Patent number
US05759443

Reaction notes

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