Dimethylamine → HCID 4190857, compound

HRID 962380Notes

Reaction equation

HRID 962380 reaction equation
[CH3:1][S:2][C:3]1[N:8]=[C:7](Cl)[CH:6]=[C:5]([Cl:10])[N:4]=1.[CH3:11][NH:12][CH3:13]>O1CCOCC1.O>[CH3:1][S:2][C:3]1[N:4]=[C:5]([Cl:10])[CH:6]=[C:7]([N:12]([CH3:13])[CH3:11])[N:8]=1

Participants

5

Reactant 2

HCID 674DimethylamineHCID 805314,6-Dichloro-2-(methylthio)pyrimidine

Product 1

HCID 4190857HCID 4190857, compoundYield 97.9%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of 46 g 2-methylthio-4,6-dichloropyrimidine in 250 ml dioxane, were added at room temperature and over a period of 10 minutes, 65.6 ml of 40% dimethylammonia-solution in water and the mixture was stirred for one hour. The solvent was evaporated and the residue purified on silica gel with toluene as eluent to give 57.0 g (97.9%) of 2-methylthio-4-chloro-6-(N,N-dimethylamino)-pyrimidine of m.p. 102° C.

Workup

  1. customThe solvent was evaporated
  2. customthe residue purified on silica gel with toluene as eluent

Sources & evidence

ORD record
ord-26e18f71fd6f43289449bd2a95c142f8
Source dataset
uspto-grants-1998_06
Patent number
US05759956

Reaction notes

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