反应详情

A mixture of 7.75 g (0.05 mole) of ethyl 4-cyano-2-oxo-butanoate in 31 g (0.225 mole) of diethyl phosphite is stirred at 20°-30° for 3-4 days. The excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-700 to yield the crude product as an oil. This is purified by chromatography on silica gel.

1. customThe excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-700