Diethylphosphite → HCID 19084730, compound

HRID 962403Notes

Reaction equation

HRID 962403 reaction equation
[C:1]([CH2:3][CH2:4][C:5](=[O:11])[C:6]([O:8][CH2:9][CH3:10])=[O:7])#[N:2].[P:12]([O-:19])([O:16][CH2:17][CH3:18])[O:13][CH2:14][CH3:15]>>[CH2:14]([O:13][P:12]([O:16][CH2:17][CH3:18])([C:5]([OH:11])([CH2:4][CH2:3][C:1]#[N:2])[C:6]([O:8][CH2:9][CH3:10])=[O:7])=[O:19])[CH3:15]

Participants

3

Reactant 2

HCID 3780918DiethylphosphiteHCID 15089956Ethyl 4-cyano-2-oxobutanoate

Product 1

HCID 19084730HCID 19084730, compound

Procedure

A mixture of 7.75 g (0.05 mole) of ethyl 4-cyano-2-oxo-butanoate in 31 g (0.225 mole) of diethyl phosphite is stirred at 20°-30° for 3-4 days. The excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-700 to yield the crude product as an oil. This is purified by chromatography on silica gel.

Workup

  1. customThe excess diethyl phosphite is removed on a rotary evaporator under high vacuum at a bath temperature of 50°-700

Sources & evidence

ORD record
ord-95e2d84b9cec41e6ba7e4936447661e7
Source dataset
uspto-grants-1998_06
Patent number
US05760021

Reaction notes

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